Medicinal plants of kakamega forests and their consistency applications doi. New xanthones from psorospermum febrifugum journal of. The aberrant viral intermediates showed dosedependent dna strand breaks and proteindna crosslinks, as well as decreased electrophoretic mobility. Psorospermum febrifugum is a flowering plant species in the genus psorospermum occurring in zimbabwe and mozambique. These phytochemicals possess antioxidative and free radical scavenging. Novel tetrahydrofurobenzofuranoxanthones from psorospermum febrifugum. Natural products as adjunctive treatment for pancreatic. We initiated our studies with 2nitrobenzofuran 1a as the substrate, given the ready availability and diverse transformation of the nitro group. The ethyl acetate fraction of the extract was administered to wistar rats in a single dose of 2000 mg kg body. It has been used for a long time in traditional medicine for the treatment of skin diseases like dermatitis, scabies, eczema and. Psorospermin, a cytotoxic dihydrofuranoxanthone isolated from psorospermum febrifugum, produced aberrant simian virus 40 dna replication intermediates when added to lytically infected cv1 monkey kidney cells. An example is the small tree psorospermum febrifugum, the trunk and root bark of which has gained. Pagka karon wala pay siak nga nalista ubos niini niya.
Phytochemistry and pharmacognosy of the genus psorospermum. When 1a was mixed with simple epoxybutene 2a under the catalysis of chiral palladium catalyst, to our disappointment, no reaction occurred with either the trost ligand l1 or the feringa ligand l2 table 1, entries 1 and 2. Complementary and alternative medicines, such as natural productsherbal medicines, represent exciting adjunctive therapies. Request pdf phytochemistry and pharmacognosy of the genus. Antioxidant activity and total phenolic content of nine. Ethyl acetate fraction of psorospermum febrifugum extract.
Wikispecies har information om psorospermum febrifugum. Background free imaging of a viral capsid proteins coated anisotropic nanoparticle on a living cell membrane with darkfield optical microscopy. The free radical scavenging activity until this point time of reaction were. Pdf psorospermum febrifugum spach hypericaceae decoction. Bulbine is most suited to cooler frost free regions with well drained soil. Prenylated bianthrones and vismione f from psorospermum. These metrics are regularly updated to reflect usage leading up to the last few days. Although herpes zoster was a frequently cited condition by the tmp, the only plant species highly cited for treating it was psorospermum febrifugum. Modern research has shown the presence of various medically active compounds, but has failed to find any action against malaria. Psorospermum spach plants of the world online kew science. A project set up by plantlife international in the village of bunza sets out to conserve and. Cytotoxic activity of these pigments against the human colon carcinoma. The plant extracts were prepared by maceration in organic solvents.
The fruit is a small berry some 6mm in diameter and bright red when mature. Various parts of the plants were dried, grounded and extracted in methanolic solvent. Espesye sa tanom nga bulak ang psorospermum febrifugum. H e a l t h a n d wealth f r o m m e d i c i n a l. Here, the anticancer, antimicrobial and antioxidant activities of ten antioxidantrich cameroonian medicinal plants and of some of their isolated compounds are evaluated. Secondly, we have showed that the plants daniellia oliveri and psorospermum febrifugum have potential as sources of lead compounds for the development of the muchneeded filaricidal drugs to treat onchocerciasis river blindness and lymphatic filariasis elephantiasis. This work aimed to evaluate the safety of the ethyl acetate fraction of the aqueous extract of this bark. Evaluation of antioxidant and antiacne activity of.
These plants could be potential rich sources of natural antioxidants and developed into functional food for nutrition and. Pdf anticancer and antimicrobial activities of some antioxidant. Leaves deciduous, opposite subopposite or alternate, shortly petiolate. Phytochemistry and pharmacognosy of the genus psorospermum phytochemistry and pharmacognosy of the genus psorospermum epifano, francesco. Scattered amongst the canopy are smaller trees mainly diospysos kirkii, faurea saligna, protea gaguedi, pseudodolachnostylis maprouneifolia and psorospermum febrifugum. Psorospermum febrifugum spach is a flowering plant belonging to the family. Anticancer and antimicrobial activities of some antioxidantrich. Psorospermin was isolated from the stembark and roots of the african plant psorospermum febrifugum 12. Activitydirected fractionation of the ethanolic extract of psorospermum febrifugum has led to the isolation and structural elucidation of eight new dihydrofuranoxanthones. Despite the therapeutic claims, literature reports, and brine shrimp assay. The roots of psorospermum febrifugum collected in malawi contained together with the known vismione d and geranyloxyemodin four new compounds.
Pancreatic cancer is a type of common malignant tumors with high occurrence in the world. Although studied for over thirty years, the four isomers of psorospermin were only recently synthesized in 2005 figure 1a. It has a long history for its use in folkloric medicines as a remedy for leprosy, epilepsy, insomnia. Six compounds were found to exhibit significant in vitro cytotoxic activity. The plant psorospermum febrifugum spach is a specie of flowering plants belonging to the family hypericaceae. Pdf antitumour and cytotoxic xanthones of psorospermum. It also protected mice against pentylene tetrazol, picrotoxinand strychnineinduced seizures. The preliminary phytochemical screening of methanol extracts for stem bark, leaves. Fra 2015 country report, zimbabwe 7 dry savannah woodlands dry savannah occurs mainly at altitudes of between and 0 masl, on the highveld. As a service to our customers we are providing this early version of the manuscript. In cameroon herbs are traditionally used to meet health care needs and plans are on the way to integrate traditional medicine in the health care system, even though the plans have not been put into action yet. Compound 1 was characterized based on spectroscopic and. Styles 5, free ovules ovules 1 2 per loculus fruits fruit a berry seeds seeds large with a fleshy glandularpunctate testa. Recent trends and advancements qingxiyue, 1,2 guoganggao, 3 gangyongzou, 4 haiqingyu, 5 andxizheng 2,6.
Psorospermum febrifugum spach is used in traditional medicine in cameroon to treat epilepsy. The ficus asperifolia and psorospermum febrifugum extracts are selective against. Stems terete or slightly flattened, densely rustytomentose. The decoction of psorospermum febrifugum slightly increased the total sleep time induced by diazepam 50 mg kg 1 i. Psorospermum febrifugum spach hypericaceae decoction. Pdf 399 kb pdf download buy article permissions and reprints. Five anthranoid pigments, including a new anthraquinone and a new tetrahydroanthracene, were isolated from the root bark of psorospermum febrifugum spach guttiferae. Sl were collected based on ethnomedical information provided by traditional herbal practitioners. Palladiumcatalyzed highly stereoselective dearomative 3. The ficus asperifolia and psorospermum febrifugum extracts are. Psorospermum febrifugum spach clusiaceae was a tropical plant whose root bark was used to treat anemia. Recent cancer drug development with xanthone structures. Pdf antipsoriatic and immunomodulatory evaluation of. A systematic fractionation of the root extract ofpsorospermum febrifugum was carried out in an attempt to reisolate the antitumor xanthone psorospermin and related compounds for further structural work and testing.
Psorospermum is a genus of flowering plants in the family hypericaceae species. This study investigated the phytochemical screening of some plant extracts against aflatoxin producing fungi in sesame sesamum indicum. Psorospermum febrifugum is widely used in traditional medicine in africa. Evaluation of antioxidant and antiacne activity of psorospermum febrifugum spach and psorospermum corymbiferum hochr. Psorospermum febrifugum spach is a flowering plant belonging to the family hypericaceae. The following 15 species are in the genus psorospermum. College of pharmacy, catholic university of daegu, gyeongsan, gyeongbuk, korea. Screening and phytochemical analysis of some plants. Furthermore, chemotherapy or radiotherapy had very limited success in treating pancreatic cancer. Psorospermum febrifugum spach is an accepted name this name is the accepted name of a species in the genus psorospermum family hypericaceae. Health and wealth from medicinal aromatic plants food and. The chemical constituents and biological activities of.
The aqueous extract of the root bark of psorospermum febrifugum. This page was last edited on 20 december 2019, at 16. The country however has a rich biodiversity, with 8,620 plant species, some of which are commonly used in the treatment of several microbial infections and a range of diseases malaria. It grows in open woodland over a wide range of altitudes. Free radical addition of butanethiol to vegetable oil double bonds. Antipsoriatic and immunomodulatory evaluation of psorospermum. Psorospermum febrifugum spach original illustration from the trees of central africa. Psorospermum corymbiferum in global plants on jstor.
The plants are prosopis africana, psorospermum febrifugum and rhizome of curcuma longa. Psorospermum febrifugum wikispecies, free species directory. The inconspicuous flowers are fragrant, creamywhite and some 8mm in diameter. Results of the study indicate that extracts from the eight plant species. This activitydirected fractionation led to the isolation of 6geranyloxy3methyl1,8dihydroxyanthrone 1.
The aqueous extract of the root bark of psorospermum. Other sources of information about psorospermum febrifugum. Wistar rats were anaemic by intraperitoneal injection of phenylhydrazine chloridrate. These plants could be potential rich sources of natural antioxidants and. Potential new drug targets and therapeutic approaches for. Psorospermum febrifugum is a flowering plant species in the genus psorospermum occurring.
This work aimed to study the therapeutic efficacy of that root bark extract on anaemia treatment. Xanthones and vismiones from psorospermum febrifugum. It is a shrub or small tree growing in the tropical regions of south america, africa and madagascar. Indigenous traditional knowledge of medicinal plants used. Ethyl acetate fraction of psorospermum febrifugum spach. Medicinal plants of kakamega forests and their consistency. High correlation has been established between antioxidant activity and total phenolic content of psorospermum febrifugum, myrianthus arboreus and ceratotheca sesamoides. Traditional remedies have a longstanding history in cameroon and continue to provide useful and applicable tools for treating ailments. Natural products as adjunctive treatment for pancreatic cancer. Psorospermin structural requirements for pglycoprotein. Ang psorospermum febrifugum sakop sa kahenera nga psorospermum sa kabanay nga hypericaceae. Most patients presented in clinic had pancreatic cancer at advanced stages. Text is available under the creative commons attributionsharealike license.1538 435 1030 452 1475 286 917 1463 857 1538 486 1681 893 1457 157 1132 247 267 1402 678 1200 181 1397 742 188 1024 515 393 1482 752 1163 584 1230 624 984 1280 1039